Supplements

Before taking nutritional supplements or herbal prepatarion, it is critical that you inform your doctor if you choose to use dietary supplements. An estimated 60% of patients choosing to use alternative/complementary therapies for their cancer did not disclose that use to their primary care doctor.

Your doctor does not have to agree with your choices, however they must be aware of your choices in order for them to provide you with safe/effective care. Supplements may have unintended negative interactions with specific medicines or medical treatments, but your doctor won’t be able to inform you of potential reactions if they don’t know what supplements you are taking.

Supplements are an important part of an integrative cancer treatment program in order to help repair physiological processes that contribute to cancer development. Impaired immunity, inflammation, endocrine disturbances, insulin resistance, and insufficient detoxification are each linked to cancer formation and can be corrected with lifestyle and supplemental interventions. Nutritional supplements are also important in the active treatment of established cancer. Many supplements have powerful anticancer effects.

The supplements you take should be chosen to meet your individual needs, deficiencies, or activity level. Qualified health-care providers can guide the most appropriate use of supplements in the context of cancer.

Below we list in no specific order, supplements we feel have important use in prevention as well as an integrative approach to cancer treatment. Our below guide is just that, a guide only.

Finding your supplements & supplement quality

It can be a daunting task finding quality supplements. iHerb can make it easier to source many supplements. Unfortunately though, quality is not always assured. If you are in Australia Chemist Warehouse also provides some supplements, and generally speaking due to Australia supplement standards quality can be more assured. We have done our best to list supplements we feel are of quality. The list is not exhaustive. To ensure quality, practitioner supplementation should be considered where possible.

Antioxidants

At high doses, most antioxidants stimulate apoptosis of cancer cells. When taken at low doses however antioxidants tend to have no effect on cancer cells.

Vitamin A

Take 50,000 IU Vitamin A (Retinol) 2-3 times per week with a meal containing fats. Compounding pharmacies are able to make a single 50,000IU capsule to minimise the amount of capsules you may need to take at one time to achieve the required dosages.

Alternatively to Vitamin A (Retinol) you may take Vitamin A as natural mixed carotenoids

Supplements
Chemist Warehouse – Blackmores Vitamin A (Retinol) 5,000IU
iHerb – Jarrow Formulas, CarotenAll

Dietary sources
Carrots, pepper, apricots, spinach and mangoes

Click here to find a compounding pharmacy near you

Vitamin B3, B5, B6

High dose B1 & B2 may have some association with cancer growth. We recommend 50mg of each B3, B5, B6 – to be taken with breakfast and lunch. A compounding pharmacists can make this supplement for you.

Click here to find a compounding pharmacy near you

Vitamin C

Oral Vitamin C with Bioflavinoids

A method of utilising vitamin C in amounts just short of the doses which produce diarrhea is described as titrating to bowel tollerance. When bowel tolerance is reached it means your body has now absorbed the maximum amount of vitamin C it is able to.

Multiple high dose oral vitamin C supplements in the 2- to 3-gram range given four to six times per day can maintain high blood plasma throughout a 24-hour period.

Liposomal Vitamin C

Studies suggest that oral bioavailability of vitamin C can be increased when consumed in liposomal form. You may take a combination of Oral Vitamin C and Oral Liposomal Vitamin C to help boost plasma levels.

Intravenous vitamin C (IV C)

IV C bypasses intestinal absorption and the associated saturable transport mechanisms. Consequently, the bio availability of vitamin C differs appreciably between oral and intravenous administration. In healthy adults, intravenous administration of vitamin C might reach blood concentrations that are 30 to 70 times higher than the same oral dose.

Intravenous protocols are generally individualised and reassessed/modified as treatment progresses and depending on the response of the individual. IV C is given daily for 2 weeks, then 2-3 times per week after that.

Dosages start at 15,000mg (15g), if well tollerated, dosages are typically increased by 15,000mg each time until a dose of 45,000mg – 90,000mg. At these high doses it is important that the IV is run over a long period of time at least 2hrs.

IV C is best used in conjunction with Intravenous alpha lipoic acid (ALA), but needs to be administered by a professional with the correct training to avoid complications.

You must be well hydrated before your IV. Possible side effects include headache if dehydrated, & minimal discomfort at the injection site on 1st occasion.

IMPORTANT: Before starting IV C, you should complete a G6PD blood test

Supplements
Chemist Warehouse – Blackmores Bio C 1000
iHerb – Dr.Mercola, Liposomal Vitamin C

Dietary Sources
Peppers, broccoli, guavas, cauliflower, strawberries, papaya

Vitamin D

Optimise your blood levels to be over 100 nmol/l

Supplements
iHerb – Thorne Vitamin D
Chemist Warehouse – Swisse – Vitamin D

Dietary Sources
Cold-water fish, dark green leafy vegetables

Vitamin E

Take d-alpha tocopheryl succinate 400 IU’s per day & mixed vitamin E that contains 4 tocopherols & 4 tocotrienols. Reduce if bruising or nose bleeds occur.

Supplements
iHerb – Life Extension – Gamma E – Mixed Tocopherols & Tocotrienols

Practitioner Product
Xymogen – Excellent E
Orthoplex – Synergy Vitamin E

Dietary sources
Whole grains, seeds, nuts

Selenium

Selenium is an important for

  • Co-factor for many enzymes
  • Helps to lower oxidative stress
  • Immunity
  • Inflammation
  • Suppression/inhibition of tumor growth
  • Re-cycling other vitamins

We however do not recommend the use of selenium in prostate cancer

Supplements
iHerb – Natural Factors SelenoExcell

Dietary Sources
Brazil nuts

CoQ10

This potent antioxidant enhances T cell and natural killer cell activity, as well as increasing the cellular production of energy and prevents cellular damage by neutralising free radicals

Take as Ubiquinol 150mg twice daily

Supplements
iHerb – Life Extenstion Super Ubiquinol CoQ10

Practitioner Products
Designs for Health – Ubiq-Evail

Dietary Sources

  • Organ meats: Heart, liver and kidney.
  • Some muscle meats: Pork, beef and chicken.
  • Fatty fish: Trout, herring, mackerel and sardine.
  • Vegetables: Spinach, cauliflower and broccoli.
  • Fruit: Oranges and strawberries.
  • Legumes: Soybeans, lentils and peanuts.

 

Alpha R-Lipoic Acid

100-500mg twice daily

Essential Fatty Acids

Essential fatty acids (EFA’s) must be obtained via the diet, and cannot be made by the body. EFA’s are split into 2 primary categories.  Omega-3 and Omega 6. In reality, there is only one essential omega-3 fatty acid called alpha-linoolenic acid (ALA), and one essential omega-6 fatty acid called linoleic acid (LA).

The body is able to manufacture omega-3 EFA’s such as EPA (eicosapentaenoic acid) and DHA (docosahexanoic acid) as well as omega-6s which include GLA (gamma-linolenic acid from these basic building blocks.

For therapeutic purposes eating cold water fish or supplementing with fish oil capsules is the best bet.

Supplements
iHerb – Nordic Naturals Ultimate Omega or Arctic Cod Liver Oil – 2caps 2-3 times per day

Practitioner Product
Orthoplex White Label – BioActive Lipids – 2 caps 2-3 times per day

Dietary Sources
Fish, shellfish, flaxseeds, sea vegetables

Curcumin

This antioxidant phytochemical (1) is derived from the spice turmeric and is able to enhance the phagocyte (2) (cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells) activities in macrophages in the immune system. It is also able to inhibit the production of inflammatory cytokines that stimulate tumor growth.

  1. Phytochemical are compounds that are produced by plants
  2. Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells

Curcumin has been shown to:

  • Suppresse inflammatory processes that can contribute to cancer development and progression
  • Helps to stimulate cancer cell death (apoptosis)
  • Anti-inflammatory, anti-iangiogenic, and antioxidant
  • Can prevent or delay cancer growth

Supplements
iHerb – Thorne Meriva-SF

Practitioner Product
BioMedica – Pure Liposomal Curcumin
Bio-Practica – Liposomal Curcuminoids

Melatonin

Melatonin is an excellent example of one of the many natural substances with significant anti-cancer actions or the ability to increase tolerance to conventional treatments.

Melatonin has been shown in many trials involving a variety of cancers to reduce a multitude of adverse effects from chemotherapy and radiation while improving overall survival.

  • Help the immune system kill cancer cells
  • Influence sleep cycles
  • Hormone Balance

Supplements

iHerb – Life Extension Melatonin

EGCG - Green Tea

Greet tea is another great example of a natural substance with a very wide variety of anticancer properties. An active ingredient in green tea EGCG ( epigallocatechin gallate), has been proven to be effective in preventing and helping to treat some forms cancer.

  • EGCG inhibits the enzyme dihydrofolate reductase (DHFR), which is a well recognised and established target for anticancer drugs
  • EGCG can kill cancer cells in the same way as methotrexate
  • Can kill cancer cells by stimulating apoptosis
  • EGCG inhibits the enymes that break down the connective tissue matrix. These enzymes can eat a pathway through connective tissue, which can allow cancer to metastasize to other parts of the body.

BioBran - (Ribraxx)

Rice bran arabinoxylan (Ribraxx)—a proprietary formulation of rice bran and shitake mushroom extract—has been extensively studied and found to have immune stimulating, anti-inflammatory, and proapoptoticn (promoting or causing apoptosis) effects.
  • Ribraxx has been previously shown to enhance NK cell–mediated cytotoxicity
  • Increase neutrophil count
  • Decrease inflammation as determined by ESR

Supplements
BioMedia – Ribraxx